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Tramadol is effective pain reliever. Tramadol is used similarly to codeine, to treat moderate to moderately severe pain and most types of neuralgia, including trigeminal neuralgia. It has been suggested that tramadol could be effective for alleviating symptoms of depression, anxiety, and phobias because of its action on the noradrenergic and serotonergic systems, such as its "atypical" opioid activity. Tramadol - Mechanism of action Tramadol acts as a μ-opioid receptor agonist, serotonin releasing agent, norepinephrine reuptake inhibitor, NMDA receptor antagonist, 5-HT2C receptor antagonist, (α7)5 nicotinic acetylcholine receptor antagonist, and M1 and M3 muscarinic acetylcholine receptor antagonist. The analgesic action of tramadol has yet to be fully understood, but it is believed to work through modulation of serotonin and norepinephrine in addition to its mild agonism of the μ-opioid receptor. The contribution of non-opioid activity is demonstrated by the fact that the analgesic effect of tramadol is not fully antagonised by the μ-opioid receptor antagonist naloxone. Tramadol - Adverse effects The most commonly reported adverse drug reactions are nausea, vomiting, sweating and constipation. Drowsiness is reported, although it is less of an issue than for non-synthetic opioids. Several patients taking tramadol for general pain relief with or without other agents have reported withdrawal symptoms including uncontrollable nervous tremors, muscle contracture, and 'thrashing' in bed (similar to restless leg syndrome) if weaning off the medication happens too quickly. Anxiety, 'buzzing', 'electrical shock' and other sensations may also be present, similar to those noted in Effexor withdrawal. Before taking tramadol You should not take tramadol if you have ever been addicted to drugs or alcohol, if you have ever attempted suicide, if you are currently intoxicated (drunk), or if you have recently used any of the following drugs: - alcohol; - narcotic pain medicine; - sedatives or tranquilizers (such as Valium); - medicine for depression or anxiety; - medicine for mental illness (such as bipolar disorder, schizophrenia); - street drugs. CLICK HERE to Buy Tramadol Online |
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